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InAlyzer DEXA Applications

The use of dual-energy absorptiometry (DEXA) to measure bone mineral content (BMC) and bone mineral density (BMD) in lab animals is key because of the need to examine bone and body composition in longitudinal studies. Small animals are commonly used by researchers in the investigation of substances that affect genetics, cell physiology, bone, and soft tissue. InAlyzer® DEXA scanning eliminates the need for time-consuming, destructive chemical analysis. 

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The measurement of bone mineral density and bone mineral content is an essential part of assessing bone loss in both humans and animals.

Bone Mineral Density (BMD)

DEXA scanning has become the most common method for measuring bone mineral density (BMD) of small animals in metabolic bone disease research. The most common bone disease in humans is osteoporosis, which is a major public health problem because of the significant morbidity, mortality and costs associated with its complications.

Laboratory rats and mice are frequently used as animal models in osteoporosis research, including hormonal interventions (ovariectomy, orchidectomy, hypophysectomy, parathyroidectomy), immobilization, and dietary manipulations. Rat and mouse skeletons have been studied extensively by DEXA because of the similarities in physiopathologic responses between human and rat/mouse skeletons. (Figures 1-5)

Measurement, InAlyzer DEXA
Figure 1: Measurement


Results, DEXA InAlyzer

Figure 2: Results


Region of Interest, DEXA InAlyzer

Figure 3: Data from the Region of Interest (ROI)


View, DEXA InAlyzer

Figure 4: View


Analysis, DEXA InAlyzer

Figure 5: Analysis


Body Composition: BMC, FAT, LEAN

DEXA scanning is a nondestructive technology to precisely and accurately measure many parameters of whole-body composition in small animals. DEXA was originally designed for noninvasive measurement of bone density, but it is now also widely used for body composition measurements. DEXA provides excellent reproducibility of data in both lean and obese lab animals. Research has demonstrated that DEXA mouse body composition measures correlate well to chemical analysis measures of body composition, but DEXA is a much faster process and assesses body composition in vivo.

Body composition analysis by DEXA is based on the characteristic “signatures” of differential attenuation of low and high energy X-rays by specific tissues.  To analyze a particular substance (eg, BMD, BMC, FAT, LEAN), researchers work with the dual energy X-ray characteristics of the material to be analyzed in order to obtain mass values in a sample. (Figures 6,7)


Body composition of a rat, DEXA InAlyzer study

Figure 6: DEXA InAlyzer study of body composition of a rat


Body composition measurement result, DEXA InAlyzer

Figure 7: Body composition measurement result


The measurement of bone mineral density and bone mineral content is an essential part of assessing bone loss in both humans and animals.

Micro Photonics Inc. provides instruments, laboratory services, training, and support from experts
to help research scientists meet their most complex laboratory demands.

Request: FREE EVALUATION SCAN to see how the InAlyzer DEXA system works with your application.

Contact: Timothy Sledz, President / COO, Micro Photonics
866-334-4MPI (4674).

Timothy Sledz, or 866-334-4MPI (4674)

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