• Applications
  • Quartz Crystal Microbalance for Protein Adsorption to Solid Surface

Quartz Crystal Microbalance for Protein Adsorption to Solid Surface

Protein adsorption to solid surfaces is of major interest in pharmaceutical sciences. The qCell T instrument, a QCM-D technology, is used to study pH-dependent adsorption of a model protein to heat-treated silicone surfaces. 

The pH dependency of protein adsorption to heated silicon surfaces was monitored by the qCell T in real-time. The frequency and damping shift suggested that the higher protein adsorption at pH 4.0 and pH 8.6 are driven by both hydrophobic and charge interactions. At pH 11.9 protein adsorption was less due to strong repulsive electrostatic forces. But hydrophobic interactions still rendered substantial adsorption. 

Visit Quartz Crystal Microbalance Applications Center
Contact Steve
Contact Steve

QCM sequence upon model protein adsorption

Typical QCM sequence of frequency decrease and damping increase upon adsorption of a model protein of 2mg/ml at pH 4 to heat-treated silicon surfaces.

Heat-treated silicone coating on gold quartz crystals

Development of a homogeneous heat-treated silicone coating on gold quartz crystals. (A.) Gold-coated quartz crystal. (B.) inhomogeneous silicone coating (manually coated). (C.) homogeneous silicone layer (spin coated).

Related Products

View All Products

Related Articles

Visit Product Education

3T Analytik qCell D and qCell T Series Overview

 What is the 3T Analytik qCell series? This series comprises the the best entry-level Quartz Crystal Microbalance with Damping/Dissapation(QCM-D) instruments available. The products offer

Ann Bagnell October 14, 2021
Visit Product Education

Not sure if Quartz Crystal Microbalance will work for your application?
Our specialists are happy to help.

Buyers’ Guide
Contact Steve

Not sure if Quartz Crystal Microbalance will work for your application?
Our specialists are happy to help.

Buyers’ Guide
Contact Steve

Quartz Crystal Microbalance Buyer's Guide




    Coming Soon:

    Customer access to tips and instructional videos, method notes, tutorials, application notes, and other content to support your research.

    Employment

    Our people are the key to our success.

    We seek and employ talented scientists who have the curiosity and knowledge to offer intelligent collaboration with the researchers who are our customers. We don’t have any openings but would be happy to receive resumes to hold on file.

     

    Please submit resumes to: info@microphotonics.com

    Micro Photonics Inc.
    1550 Pond Road, STE 110
    Allentown, PA 18104

    Tel: 1-866-334-4MPI (4674)
            (610) 366-7103
    Fax: (610) 366-7105

    Events

    CONFERENCES

    WVC Annual Conference
    Las Vegas, NV
    February 19-21
    Booth 1484

    ORS
    February 8-10, 2025
    Phoenix, AZ
    Website

    MD ANDERSON PRECLINICAL IMAGING CONFERENCE
    April 9-11, 2025
    MD Anderson
    Houston, TX

    AALAS
    November 9-13, 2025
    Long Beach, CA
    Website

     

    Privacy Policy

    What information do we collect? We collect information from you when you register on our site, place an order, subscribe to our newsletter or fill out a form. When ordering or registering on our site, as appropriate, you may be asked to enter your: name, e-mail address, mailing address, phone number or credit card information. You may, however, visit our site anonymously.
    What do we use your information for? Any of the information we collect from you may be used in one of the following ways:

    ; To personalize your experience (your information helps us to better respond to your individual needs).

    ; To improve customer service (your information helps us to more effectively respond to your customer service requests and support needs).

    ; To process transactions. Your information, whether public or private, will not be sold, exchanged, transferred, or given to any other company for any reason whatsoever, without your consent, other than for the express purpose of delivering the purchased product or service requested.

    ; To send periodic emails .The email address you provide for order processing, will only be used to send you information and updates pertaining to your order.Note: If at any time you would like to unsubscribe from receiving future emails, we include detailed unsubscribe instructions at the bottom of each email.

    Terms and Conditions

    Terms of Service for www.microphotonics.com

    Introduction. Welcome to www.microphotonics.com. This website is owned and operated by Micro Photonics Inc. By visiting our website and accessing the information, resources, services, products, and tools we provide, you understand and agree to accept and adhere to the following terms and conditions as stated in this policy (hereafter referred to as ‘User Agreement’), along with the terms and conditions as stated in our Privacy Policy (please refer to the Privacy Policy section below for more information).

    This agreement is in effect as of October 25, 2018.

    We reserve the right to change this User Agreement from time to time without notice. You acknowledge and agree that it is your responsibility to review this User Agreement periodically to familiarize yourself with any modifications. Your continued use of this site after such modifications will constitute acknowledgment and agreement of the modified terms and conditions.

    Responsible Use and Conduct. By visiting our website and accessing the information, resources, services, products, and tools we provide for you, either directly or indirectly (hereafter referred to as ‘Resources’), you agree to use these Resources only for the purposes intended as permitted by (a) the terms of this User Agreement, (b) the terms of any applicable confidentiality, non-disclosure, or other agreement between you and a third party, and (c) applicable laws, regulations and generally accepted online practices or guidelines.

    Quartz Crystal Microbalance Buyer's Guide




      Talk to a Quartz Crystal Microbalance specialist about your application

      Call Now Button