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SkyScan 1076 Micro-CT System
Low Dose In-Vivo Scanning of Small Specimens

The Skyscan 1076 is a low dose in-vivo x-ray micro-CT scanner for slice imaging and 3D image reconstruction from small animals such as mice and rats. The images have pixel sizes as fine as 9 microns.  The Micro CT technique is non-invasive and can capture a cross-section up to 17 mm in length along any region of the specimen. The data can be used to create realistic 3D images and to calculate internal morphological parameters.

 

See our applications page for a more detailed look

 

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2D & 3D Analysis Software
Micro-CT Attachment Kit for SEM

 

Implemented in the SkyScan 1076 is an ultra fast, high resolution X-ray camera. This state-of-the-art detector allows for faster scans and reduces the exposure to the animal while still maintaining the large field of view. Combined with the latest “List Mode” acquisition function it is now possible to obtain digital synchronization for lung imaging without have to inhibit the specimen. In List Mode operation, multiple images are taken in a fraction of a second and digitally synchronized post-acquisition in the NRecon reconstruction software.

 

Mouse Knee

High Resolution Scan

9 microns

 

3D rendering with front top part virtually removed (CTan+CTvol programs)

 

Arthritic Mouse Paw

Download full AVI movie here (12Mb).

 

Medium Res. Scan

18 micron pixel

 

Tissue Analysis

35 micron pixel scan

 

 

BONE

 

LUNG

3D modeling using CTAn and CTVol software

 

ADIPOSE TISSUE

LEAN TISSUE

Visit our applications page for examples

 

Specifications

 
1076
X-Ray Source
X-ray Source
10W, <5um spot size, >10000h expected lifetime, air cooled sealed type
Energy Range
Continuously variable peak energy 20-100kV
X-ray Filtering
0.5mm aluminum filter, 4-positions automatic filter changer for energy filtration
X-ray Exposure to Animal
0.1-0.5 Gy per scan typical
X-Ray Detector
CCD
12bit cooled digital X-ray camera with fiber-optic coupling to scintillator
Number of Pixels
10 Megapixel (4000x2650)
Detectability
9-14um
Maximum Object Size for Reconstruction
Single Scan
20 mm single scan length x 68mm diameter
Multi- Scan Mode
210mm length x 68mm diameter (20mm steps)
Scanning System
Source-Detector Pair
Source-detector pair rotation with 0.02 deg. min. step size, 50um object positioning accuracy with 400mm travel, 50mm camera positioning/alignment with 1um accuracy, <10 microns overall stability during scanning
Reconstruction Array
 
Pixel Size
1.
9um
2.
18um
3.
35um
Format
1000x1000 pixel to 8000x8000 pixel cross-section format
Other Specifications
Host Computer

Dual Intel Xeon 3.0GHz (512KB cache), 400MHz system bus, 1GB PC800 RAM (up to 4GB-optional), internal DVD-writer, 160 GB HDD, 20" LCD Monitor 1600x1200pixels, 32MB graphical card with 3D-accelerator, PCI Digital Frame Grabber, integrated 10/100 network and sound, MS IntelliMouse with wheel, optional dye sublimation printer with true photo quality, Microsoft Windows-XP Professional

Software Package

Source and camera control, preview (35x200mm scan), acquisition for reconstruction, volumetric (cone-beam) reconstruction of one / several / all cross sections, ROI-reconstruction, local density measurements in HU, 3D-rendering, virtual manipulation with reconstructed object, morphological analysis in 2D and 3D

Data formats BMP for results and 3D-movies, conversion to TIFF, JPG, AVI, DICOM
Reconstruction algorithm Networkable multithread reconstruction by modified Feldkamp algorithm with volumetric (cone-beam) geometry.
Reconstruction program can run with virtually unlimited number of PCs in the cluster and perform adaptive task distribution according to automatically measured PC performance and network bandpass.
Radiation safety <1uSv/h average during full scan at 20cm from the instrument surface
Installation requirements Power 100-130V/4A/50-60Hz or 200-240V/2.5A/50-60Hz, 18-25C temperature, <85% humidity, vibrations 0.1…100Hz <40 microns
Size/Weight Desk top instrument 1500 x 800 x 780mm / 150Kg + computer, monitor, keyboard, mouse and printer

Animal Monitoring

Animal holder:
Carbon composite object bed 65mm diameter / 400mm length
Carbon composite object bed 33mm diameter / 400mm length

X-ray Energy Selection:

Continuously variable peak energy 20...100kV in the source,
Automatic filter changer with 4 positions (no filter, Ti 0.025mm, Al 0.5mm, Al 1.0mm >99.9%purity)

Animal's physiological monitoring subsystem:

Miniature CMOS-camera with white LEDs illumination for real time animal's visualization during scanning,
Real-time local body movement detection for non-contact scanning synchronization with breathing,
Air / gas flow sensor for scanning synchronization with breathing,
Sensor for animal temperature measurement,
Animal's heating by airflow on the object bed,
ECG-amplifier with "x-ray invisible" connections to the animal's body,
Software package for animal physiological monitoring (temperature measurement and stabilization, body movement detection, pulse rate measurement in breathing and heart activity, etc.) and support for scanning synchronization with local body movements / breathing / heart rate
Click here for more information on the physiological monitoring system
 

 

Other Applications
Biomedical | Building Materials | Composites | Diamonds | Electronics | Food, Seeds Geology | Micro devices | Micro Fossils | Polymers | Wood, Paper | Stereo Images

 

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Micro Photonics Inc.
PO Box 50443
Irvine, CA 92619-0443
Tel: (949) 461-9292 Fax: (949) 461-9232
PO Box 3129 
Allentown, PA 18106-0129 
Tel: (610) 366-7103 Fax: (610) 366-7105