SkyScan 1176 Micro-CT
The SkyScan 1176 is a high performance in vivo micro-CT scanner for preclinical research. The large format 11 megapixel X-ray camera gives an unrivalled combination of resolution, image field size and scan speed — everything that is required in a busy and demanding biomedical research laboratory. Image field width up to 68 mm allows full body mouse and rat scanning and distal limb scanning for big animals, such as rabbits, at pixel sizes of 9, 18 and 35µm. Variable X-ray applied voltage and filters provide scanning flexibility to allow imaging of a wide range of samples from lung tissue to bone with titanium implants. Animal beds for rats and mice are available made of carbon fiber or polystyrene foam. An integrated physiological monitoring subsystem provides breathing and heart-beat gating for proven thoracic image improvement by synchronized acquisition.
For high resolution Ex Vivo scanning be sure to check the SkyScan 1172.
The full range of SkyScan software is supplied, including fast volumetric reconstruction, software for 2D / 3D quantitative analysis and for realistic 3D visualization. The software for 4D time-resolved microtomography is also supplied as standard. The scanner can work in "push button" mode with scanning start/stop and protocol setting from the integrated touch screen. The touch screen has a force sensitive surface allowing normal response while wearing gloves. The main control rack-mounted workstation is integrated below the scanner. The scanner can be optionally supplied with an integrated cluster of four powerful workstations placed in the lower part of the scanner's body.
Introduction to X-ray Microtomography (Micro-CT)
Microtomography uses a similar technique as X-ray tomography systems used in medicine (CT Scans) but with much finer resolution. Multiple 2D X-ray images are stored while either the sample or the source / detector pair is rotated. Internal structures are reconstructed as a series of 2D cross sections (up to 2400 slices in a single rotation) which are then used to analyze the two and three dimensional morphological parameters of the object. The process is nondestructive and requires no special preparation of the specimen. For comparison, medical CT systems have pixel sizes in the range of 1mm, the SkyScan 1176 Microtomograph can acquire images with 9 micron pixel size.
The powerful imaging capabilities of X-ray tomography are now available in a range of desktop instruments suitable for microscopic imaging of small objects with a wide range of applications: 3D bone analysis, food studies, soft tissue research, insects, microelectronics, materials, geological studies and more. Specialized software (CTAn) has been developed for the analysis of Micro-CT images including bone morphometry, porosity, fractal analysis and more (see related pages).
- Maintenance-free 90 kV microfocus X-ray source, automatic 6-position filter changer
- Fully distortion corrected 11 Mp X-ray camera
- Up to 8000 x 8000 pixels in every slice
- Down to 9 micron in-vivo 3 D spatial resolution
- Full body mouse and rat scanning, 68mm field of view, 200mm scanning length
- Large animal (rabbit) periphery scanning with 68mm scanning diameter
- Short scanning time: down to 73sec (1Kx1K slices)
- Integrated physiological monitoring (breathing, movement detection, ECG) for gating or time-resolved 4D microtomography
- Fully 64-bit system (including control PC and optional cluster) under Windows 7
- Embedded touch screen display
- Software for 2D/3D image analysis, bone morphology and realistic visualization
- X-ray source
Continuous variable from 20 - 90kV, 15 micron typical spot size; 25W maximum power, air cooled sealed type.
- X-ray detector
11 Megapixel (4000 x 2670) 12-bit cooled digital X-ray CCD camera with fibre optic coupling to scintillator
- 6-positions automatic filter changer for energy selection
No filter, Al 0.2mm, Al 0.5mm, Al 1mm, Al 0.5mm + Cu 0.03mm, Cu 0.1mm (all filters > 99.9% purity)
- Nominal resolution (detail detectability)
9 / 18 / 35 micron
- Low contrast spatial resolution
15 micron (10%MTF)
- Max Scanning diameter
68mm or 35mm
- Scan length
up to 200mm (20mm in one scan)
- Minimum Scan Time
Shortest scanning time is 73sec (1Kx1K slices).
- Reconstruction Arrays
cross section format (isotropic grid): up to 4000 x 4000 for 35mm FOV and up to 8000 x 8000 pixels for 68mm FOV.
- Physiological Monitoring
All scanners include Physiological Monitoring subsystem for real-time visual monitoring and movement detection, synchronization with breathing and heart activities and keeping stable preselected animal temperature.
- Animal Beds
Carbon composite beds for mouse (35mm) and rat (68mm), bed 68mm with 580x470mm tray for large animals (rabbits), foam holders for ex-vivo and peripheral scanning
- Radiation safety
< 1 µSv/h at any point on the instrument surface during scanning