SkyScan 1176 : A High Performance in Vivo Micro-CT Scanner
The SkyScan 1176 Micro-CT is a high performance, in-vivo 3D imaging scanner for preclinical research, providing an unrivalled combination of resolution, image field size, and scan speed. The large format 11 megapixel X-ray camera gives an unrivalled combination of resolution, image field size and scan speed — everything that is required in a busy and demanding biomedical research laboratory. Image field width up to 68 mm allows full body mouse and rat scanning and distal limb scanning for big animals, such as rabbits, at pixel sizes of 9, 18 and 35µm. Variable X-ray applied voltage and filters provide scanning flexibility to allow imaging of a wide range of samples from lung tissue to bone with titanium implants. Animal beds for rats and mice are available made of carbon fiber or polystyrene foam. An integrated physiological monitoring subsystem provides breathing and heart-beat gating for proven thoracic image improvement by synchronized acquisition.
For high resolution Ex Vivo scanning be sure to check the SkyScan 1272.
The full range of SkyScan software is supplied, including fast volumetric reconstruction, software for 2D / 3D quantitative analysis and for realistic 3D visualization. The software for 4D time-resolved microtomography is also supplied as standard. The scanner can work in “push button” mode with scanning start/stop and protocol setting from the integrated touch screen. The touch screen has a force sensitive surface allowing normal response while wearing gloves. The main control rack-mounted workstation is integrated below the scanner. The scanner can be optionally supplied with an integrated cluster of four powerful workstations placed in the lower part of the scanner’s body.
Introduction to X-ray Microtomography (Micro-CT)
Microtomography uses a similar technique as X-ray tomography systems used in medicine (CT Scans) but with much finer resolution. Multiple 2D X-ray images are stored while either the sample or the source / detector pair is rotated. Internal structures are reconstructed as a series of 2D cross sections (up to 2400 slices in a single rotation) which are then used to analyze the two and three dimensional morphological parameters of the object. The process is nondestructive and requires no special preparation of the specimen. For comparison, medical CT systems have pixel sizes in the range of 1mm, the SkyScan 1176 Microtomograph can acquire images with 9 micron pixel size.
The powerful imaging capabilities of X-ray tomography are now available in a range of desktop instruments suitable for microscopic imaging of small objects with a wide range of applications: 3D bone analysis, food studies, soft tissue research, insects, microelectronics, materials, geological studies and more. Specialized software (CTAn) has been developed for the analysis of Micro-CT images including bone morphometry, porosity, fractal analysis and more (see related pages).
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