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InAlyzer DEXA Systems

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The InAlyzer DEXA scan can analyze bone mineral density (BMD) and body composition (BMC, FAT, LEAN) of live lab animals in units of 0.001gm with simple anesthesia and without dissection. Serial assessment is possible for each live lab animal, saving animals and cost. Radiation exposure of researchers is blocked with internal protection, making the InAlyzer safe, effective, and accurate for use in the preclinical research phase.

Mouse and InAlyzer DEXA system

Save time, cost, and animals

Bone mineral density and body composition measurements can be obtained from the InAlyzer in as little as a minute using simple anesthesia without dissection. By comparison, chemical analyses can take up to an hour (homogenization, scraping, cleaning, measurement of weight, drying, chemical extraction, additional measurement of weight, etc.) and drying or ashing of chemical extraction takes several days.

Effects due to treatments can be better traced since the same animal is being measured through out the study, removing any variability between animals.  By using fewer lab animals, the InAlyzer saves the cost of not only the animals, but the chemicals, food, and equipment and can also minimize the operation rate of the equipment. Without needing the dissection of lab animals for every serial assessment, 500~1000 animals can be saved annually.

Automated, accurate, and precise measurement

The InAlyzer DEXA systems provide automated, accurate, precise measurement of bones and tissues for small animals (eg, mice, lemmings, and rats) from 10 – 500 gm,  as well as for intermediately-sized animals weighing from 500 – 3000 gm. (Error of Precision & Error of Accuracy < 1%, Standard of Bone: static condition).

The InAlyzer is ideal for longitudinal studies because of its precise measurements of BMD and Fat.

Options for animals from 10 – 3000gm

The InAlyzer has an optional model with a large measuring area of 210mm x 315mm for use with intermediately-sized animals, such as rabbits and guinea pigs, as well as a basic model with a scan area of 140mm x 210mm for small animals, such as mice and rats.

The full size of the scan area inside the cabinet can be utilized for scanning and represents the maximum size of the measurable area, as long as the thickness is not over 100mm.

 

How it works

DEXA technology uses two X-rays beams of different types of energy to examine an animal or specimen. High-energy X-rays have small attenuation as the X-ray beam traverses matter, while low-energy X-rays have large attenuation. The amount of X-ray energy absorbed during the beam’s passage through a material is affected by the material’s thickness, density, and atomic number. What gets absorbed and what passes through depends on the material’s composition. To analyze a particular substance (eg, BMD, BMC, FAT, LEAN), researchers work with the dual energy X-ray characteristics of the material to be analyzed in order to obtain mass values in a sample.  The system is calibrated so that analysis of these parameters is built into the system.

Comparison to other technologies

DEXA scans and micro-CT instruments are often considered complimentary instruments.  The speed of the DEXA scans allows researchers to quickly and routinely get measurement in 2D of BMD, BMC, and lean body.  Micro-CT allows you get detailed 3D slice by slice information and can be calibrated for bone quality and lean body analysis as well.  Labs often have one each of these instruments.

BIA (Bioelectrical Impedance Analysis) technology for body composition analysis is impossible to apply to small animal because the path for analysis is too small and electrodes are difficult to attach. Basically, BIA analysis provides a lower accuracy than DEXA scanning.

DEXA is known to be the most accurate technology for measuring osteoporosis and obesity by measuring bone density and body composition of the human body.  This can now be applied to preclinical research in living animals.

Analysis

The analysis package provides values for BMD, BMC (bone mineral content), Fat, and Lean for the material in the entire scan area. It also provides the total mass derived from each component as well as the ratio of each component to the total mass.

Along with the default analysis, the system includes 30 ROI (Region Of Interest),10 XROI (eXclude ROI), 30 CROI (Customizable ROI), and 10 CXROL (Customizable XROI).  The ROI is a rectangle and the CROI is a spline shape; both functions can be resized and rotated. Both ROI and CROI may be used to perform analysis on specific areas, and areas may be removed from analysis using XROI and CXROI.

The analysis screen provides images for an energy X-ray, bone, and body composition. The body composition image is provided in color so that it is easy to visualize the part with high body fat percentage. A simple ruler is supplied on the image with easy zoom capability.

Features

Longitudinal studies

Data may be gathered for the same subjects repeatedly over a study period with minimal harm to the animal subjects, using simple anesthesia and no dissection.

High resolution images

The InAlyzer provides high-resolution images of 5.0 lp/mm, enabling structural analysis as well as providing various images, such as bone and body composition images, for easy analysis.

Compact size & safety

The InAlyzer is a compact desktop instrument. Internal lead shielding effectively protects researchers from radiation exposure, making the instrument safe for extended use.

Easy documentation

Reports are easy to generate because objective data and images can be stored in external file formats, such as Excel and Tiffs.

Monitoring camera

The built-in, real-time camera allows you to observe movement of the animal in the scanning area.

Access point for anesthesia

Anesthesia is used in many animal studies to immobilize animals while scanning or imaging. The InAlyzer provides an access point to allow continuous anesthetic gas flow and ensure complete animal immobility during imaging.

Selectable scan time

The InAlyzer can measure in three modes: Quick (1 min), Optimum (3min), and Accuracy (5min), according to the level of accuracy required.

Contact Tim Sledz via email at tim@microphotonics.com , or by phone (610) 366-7103

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