Micro-CT Applications for Covid-19 Research

Novel Coronavirus SARS-CoV-2, from the National Institute of Allergy and Infectious Diseases (NIAID).

Virologists and Lung Disease Specialists Commission Bruker´s Micro-CT for some of the World’s First in vivo COVID-19 Imaging Experiments

Reprinted from the Lab Bulletin: Jul 27, 2020  |  author/source: Bruker Corporation

Bruker’s BioSpin PreClinical Imaging Division reports the use of the Bruker SkyScan 1278 in vivo micro-CT system at the KU Leuven, Belgium, to support COVID-19-focused research. This research will leverage the university’s expertise in preclinical testing to study the efficacy of vaccine and drug candidates in COVID-19 infection models. These will be some of the first in vivo imaging experiments on COVID-19 models using mice and hamsters. It will also allow researchers to better understand how the SARS-CoV-2 virus leads to lung damage.

As one of the trustworthy methods in diagnosing lung pathology in a clinical setting, computed tomography (CT) is found to be ideally suited for diagnosing COVID-19 virus-induced lung infections. This technique is now being translated to laboratory animals for preclinical research towards finding an efficient vaccine and antiviral drugs.

Significant groundwork on diseased lung imaging has been made by the KU Leuven team led by Professor Vande Velde using the SkyScan 1278 at MoSAIC, which now collaborates with the laboratory of Virology of Prof. Johan Neyts from the Rega Institute and the Laboratory of Clinical and Epidemiological Virology, led by Professor Marc Van Ranst, for COVID-19 research.

The REGA Institute is dedicating its Biosafety Level 3 (BSL3) laboratory to COVID-19 research, recently installing KU Leuven’s second SkyScan 1278 instrument. Professor Johan Neyts, virologist commented: “We are developing a vaccine for the prevention and drugs for the treatment of COVID-19 infections. The new micro-CT scanner will help us identify which of these candidates could make it through to clinical trials.”

Professor Greetje Vande Velde, Principal Investigator at the core facility Molecular Small Animal Imaging Center (MoSAIC) and at the KU Leuven Faculty of Medicine, explained: “We have implemented micro-CT protocols for various lung disease models such as fungal infections or influenza virus infection. [1]. It has been possible to translate these into COVID animal models, to apply non-destructive in vivo imaging to examine SARS-CoV-2-based lung infections and potential treatments. The low radiation dose possible with the SkyScan 1278 is a really important development – we can image the same animal repeatedly, obtaining high quality 3D images over long time periods without harming the animal.”

Bruker offers the world’s fastest, low-dose, high-throughput micro-CT, the SkyScan 1278, which enables non-invasive, longitudinal imaging studies to obtain quantitative data on lung disease processes and treatment responses. The new micro-CT spatial beam shaper reduces the absorbed dose by up to five times while maintaining high quality image output.

The KU Leuven MoSAIC houses state-of-the-art in vivo imaging infrastructure and expertise for the non-invasive and longitudinal assessment of preclinical disease and therapy models in a biosafety level 2 (BSL2) environment. MoSAIC is well-equipped with Bruker imaging systems, including a 9.4T MRI system, a 7T PET/MRI scanner, a SkyScan 1076 micro-CT and a SkyScan 1278 micro-CT.

Prof. Vande Velde and Prof. Neyts work together in a translational approach, combining expertise in micro-CT imaging technology and virology, respectively, to tackle the modern threat of COVID-19.

For more information on the SkyScan 1278 micro-CT scanner, please visit https://www.microphotonics.com/products/skyscan-1278/.


Related Articles: Coronavirus Information and Resources

Micro Photonics Inc. provides instruments, laboratory services, training, and support from micro-CT experts
to help research scientists meet their most complex laboratory demands.

More information: FREE BUYERS’ GUIDE

Request: FREE EVALUATION SCAN to see how micro-CT works with your application.

Contact: Benjamin Ache, Product Manager, Bruker Micro-CTs P: 610-366-7103 ext 115.

Related Products

Related Articles

US Partner Form

    Coming Soon:

    Customer access to tips and instructional videos, method notes, tutorials, application notes, and other content to support your research.


    Service Engineer opening for Micro-CT Systems

    We are looking for a service engineer to join our team of experts in helping advance research by providing technical support and maintenance for micro-CT systems across the United States.

    Please submit resumes to: info@microphotonics.com

    Micro Photonics Inc.
    1550 Pond Road, STE 110
    Allentown, PA 18104



    WVC Annual Conference

    Las Vegas, NV
    February 19-21
    Booth 1484

    Privacy Policy

    What information do we collect? We collect information from you when you register on our site, place an order, subscribe to our newsletter or fill out a form. When ordering or registering on our site, as appropriate, you may be asked to enter your: name, e-mail address, mailing address, phone number or credit card information. You may, however, visit our site anonymously.
    What do we use your information for? Any of the information we collect from you may be used in one of the following ways:

    ; To personalize your experience (your information helps us to better respond to your individual needs).

    ; To improve customer service (your information helps us to more effectively respond to your customer service requests and support needs).

    ; To process transactions. Your information, whether public or private, will not be sold, exchanged, transferred, or given to any other company for any reason whatsoever, without your consent, other than for the express purpose of delivering the purchased product or service requested.

    ; To send periodic emails .The email address you provide for order processing, will only be used to send you information and updates pertaining to your order.Note: If at any time you would like to unsubscribe from receiving future emails, we include detailed unsubscribe instructions at the bottom of each email.

    Terms and Conditions

    Terms of Service for www.microphotonics.com

    Introduction. Welcome to www.microphotonics.com. This website is owned and operated by Micro Photonics Inc. By visiting our website and accessing the information, resources, services, products, and tools we provide, you understand and agree to accept and adhere to the following terms and conditions as stated in this policy (hereafter referred to as ‘User Agreement’), along with the terms and conditions as stated in our Privacy Policy (please refer to the Privacy Policy section below for more information).

    This agreement is in effect as of October 25, 2018.

    We reserve the right to change this User Agreement from time to time without notice. You acknowledge and agree that it is your responsibility to review this User Agreement periodically to familiarize yourself with any modifications. Your continued use of this site after such modifications will constitute acknowledgment and agreement of the modified terms and conditions.

    Responsible Use and Conduct. By visiting our website and accessing the information, resources, services, products, and tools we provide for you, either directly or indirectly (hereafter referred to as ‘Resources’), you agree to use these Resources only for the purposes intended as permitted by (a) the terms of this User Agreement, (b) the terms of any applicable confidentiality, non-disclosure, or other agreement between you and a third party, and (c) applicable laws, regulations and generally accepted online practices or guidelines.

    Call Now Button