Micro-CT Applications for Product Development

3D Micro-CT scan of a polyelectrolyte complex (PEC) film used as an excipient for the formulation of active agents in drug delivery systems. Credit; “Micro-Computed Tomography (Micro-CT) Analysis as a New Approach for Characterization of Drug Delivery Systems”, Kılıçarslan, Müge, et al, Micro-computed Tomography (micro-CT) in Medicine and Engineering. Springer, Cham, 26 July 2019.

Micro-Computed Tomography (Micro-CT) Analysis as a New Approach for Characterization of Drug Delivery Systems

ABSTRACT

This study evaluates the effectiveness of micro-CT for the in vitro and/or in vivo characterization and evaluation of drug delivery systems (granule, tablet, dome matrix, micro- and nanoparticle, scaffold, film, implant, in situ implant, etc.). Some of the in vitro micro-CT analysis data on different types of drug delivery systems (complex film and nanoparticle) is also presented. The study concludes that micro-ct is an effective tool for the development of drug delivery systems, due in part to the ability to perform several quantitative analyses , such as size and volume analysis, in addition to three-dimensional imaging.

READ MORE on using micro-CT for the development of drug delivery systems from Springer Link.

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Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing

ABSTRACT

“The aim of this study was to manufacture 3D printed tablets (printlets) from enteric polymers by single filament fused deposition modeling (FDM) 3D printing (3DP).” The study helps demonstrate that 3D printing can produce delayed release printlets without the need for an outer enteric coating, and the feasibility to adapt the release profile in response to the personal characteristics of the patient. Micro-CT analysis is useful in “realizing the full potential of additive manufacturing in the development of personalised dose medicines”.

READ MORE on using micro-CT for developing printlets from the International Journal of Pharmaceutics.

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Comparison of medical and industrial X-ray computed tomography for non-destructive testing

ABSTRACT

Industrial micro-CT scanning is a laboratory-based non-destructive testing technique used in a variety of applications for samples ranging from 1mm to typically about 300mm in diameter. Micro-CT scanners are used for industrial non-destructive testing due to the superior resolution possible compared to medical CT scanners. This study demonstrates that medical CT can be useful for large numbers of samples that only require moderate resolution. Micro-CT remains the technology of choice for most industrial applications because of its superior resolution, but there is room for both methods in many industrial settings. “ This is the first direct quantitative comparison between industrial CT and medical CT reported in the scientific literature.”

READ MORE on using micro-CT for industrial nondestructive testing, from Science Direct.

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Related Article: Customer Feature: Micro-CT for Personal Hygiene Product Development

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